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Defects in complex I are among the most common causes of mitochondrial diseases, contributing to disorders such as Leigh syndrome, mitochondrial encephalomyopathy and Parkinsons disease by disrupting ATP production and elevating oxidative stress 21,71,72,73

Typically, patients report complaints of both pain and paresthesia in the distribution area of the median nerve, which includes the palmar surface of the thumb, the radial part of the ring finger, and the index and middle fingers