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Nevertheless, at fairly high concentrations, NO takes on antitumor-agent properties to accelerate tumor-cell death and to inhibit tumor-cell angiogenesis

While generally safe, they should be used under medical supervision to avoid potential side effects or interaction.

Lysyl oxidase, the copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin (a step required for the cross-linking that gives mature collagen and elastin their mechanical properties), requires copper as a cofactor

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