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Szymaski , Skopek R, Palusiska M, Schenk T, Stengel S, Lewicki S, et al

Overall, the evidence remains mixed, with stronger associations observed in adults than in adolescents

It is due to the inactivation of the glutathione (GSH)-dependent antioxidant defense mechanism in cells, and the ability of GPX4 to suppress lipid ROS accumulation is inhibited, which eventually leads to lipid peroxidation and cell death ( Three factors are closely related to ferroptosis: iron, polyunsaturated fatty acids, and amino acids

These factors are important to consider in the quest to enhance antiaging influences and expand the healthspan of humans in the future [9, 16]