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It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as well as DNA methylation process, later shown to have significant impacts in various psychiatric diseases

Linskens, I

[12] [13] Therefore, if a human glutathione S -transferase is a homodimer in the pi-class subfamily 1, its name will be written as "hGSTP1-1." The early nomenclature for GSTs referred to them as Y proteins, referring to their separation in the Y fraction (as opposed to the "X and Z" fractions) using Sephadex G75 chromatography

This pervasive presence can be traced back to the infiltration of immune cells and an escalated overexpression of inflammatory cytokines by these immune cells (5, 9, 10)