To understand how AFs metabolites might interact with HSA, we computationally investigated the binding affinity of AFs and AF-derived metabolites and HSA binding sites
Furthermore, linkers modified at the 1,3-positions on 6-membered rings ( 7b and 7c ) showed the highest reactivity, followed by those on 5- and 7-membered rings ( 7d and 7f )
Nature 555(7695):210215 Huang Y, Shan Y, Zhang W et al (2023) Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes
For a substance or method to be added to the List, it must be determined that it meets at least two of the following three criteria: It has the potential to enhance or enhances sport performance It represents an actual or potential health risk to athletes It violates the spirit of sport The full 2024 List was published on 28 September 2023, giving more than three months notice to athletes, their entourage, and other stakeholders, enabling them to acquaint themselves with any modifications
