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also plasma and gastrointestinal tract Non-microsomal enzymes catalyze all conjugation reactions except glucuronidation Nonspecific esterases in liver, plasma, gastrointestinal tract hydrolyzed drugs containing ester linkages, including Succinylcholine (Anectine), Atricurium (Tracrium), Mivacurium (Mivacron), Esmolol (Brevibloc) as well as ester-type local anesthetics