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The Wnt/-catenin pathway benefits ferroptosis by promoting -catenin binding to TCF/LEF transcription factors, which in turn reduces GPX4 activity and increases lipid peroxidation ( 4 Effects of plant polysaccharides on cancer treatment via ferroptosis Polysaccharides possess significant anticancer potential by inhibiting cancer cell growth, regulating immunity, improving the cancer microenvironment, and overcoming drug resistance

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