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Last reviewed: July 18, 2026 Last updated: July 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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It has been reported that the excessive ROS generation and metal ions released from internalized metal-based NPs have an impact on multiple cell signaling pathways, mainly including Janus kinase/signal transducers and activators of transcription (JAK-STAT), nuclear factor-kappa-lightchain enhancer of activated B cells (NF-B), Phosphatidylinositol 3-kinase (PI3K)/protein serine threonidase (Akt), mitogen-activated protein kinase (MAPK), and nuclear factor erythroid 2-related factor 2 (Nrf2) (Ko et al., 2016