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Dendritic Spine Formation and Neural Connectivity in Preclinical Models Dihexa has been evaluated in multiple preclinical models of cognitive impairment: Scopolamine-Induced Amnesia: Scopolamine blocks muscarinic acetylcholine receptors, producing temporary amnesia in rodents

In short, the PD gut microbiome tends to harbor fewer good SCFA-producing, anti-inflammatory bugs and more bad pro-inflammatory, mucus-depleting bugs

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This inhibition results in reduced expression of key osteogenic markers, such as alkaline phosphatase (ALP) and osteocalcin, which are essential for the proper differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs)