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The FDA reviewed 5 reports with 109 humans: 24 healthy volunteers rectal 53-person Ulcerative Colitis trial rectal 17 knee-pain patients intra-articular 12 bladder-pain patients intravesical 2 healthy volunteers IV The FDA has 4 broad reasons against BPC: - The substance is poorly characterized

no published human pharmacokinetic data confirms what fraction of a nasal spray dose reaches the bloodstream

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