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Although a gold standard in exogenous substances behavior studies, Caco-2 cell monolayers exhibit certain limitations such as a much higher transepithelial electrical resistance (TEER, up to 500 cm 2 ) compared to the human intestine (1269 cm 2 ), overestimated P-gp-mediated efflux and low paracellular permeability, a lack of metabolic mucus and enzymes at their apical side, which limits the relevance of the Caco-2 cell line in metabolism studies under standard culture conditions (Thummel, 2007)

The ascorbate-glutathione--tocopherol triad in abiotic stress response

NMs are efficient carriers for delivering therapeutic agents to specific target regions in the brain

Muscle-Specific Effects In skeletal muscle specifically, these signaling events promote muscle fiber hypertrophy (increased muscle cell size), activation and proliferation of satellite cells (muscle stem cells that can fuse with existing fibers or form new fibers), increased myofibrillar protein content and contractile capacity, and overall muscle mass accretion