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Importantly, adipocyte-specific PGC-1 deficiency also markedly blocks the effects of TFEB overexpression on the induction of browning genes in WAT, as well as diet-induced weight gain and adiposity, suggesting that these metabolic phenotypes of TFEB overexpression are PGC-1-dependent

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Take your dose 2 to 3 hours after dinner so that your stomach is relatively empty

PLGA and other biodegradable carriers can readily be functionalized with GSH-cleavable linkers or redox-sensing moieties, providing clinically tractable routes to translate GSH-responsive designs into precision treatments [23]