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Recent findings show that the abundance of oral pathogens and plaque index are positively correlated with circulating TMAO levels (Hernndez-Ruiz et al., 2024), and elevated TMAO can in turn exacerbate periodontal inflammation and alveolar bone resorption (Wang et al., 2022)

For instance, those dual effects are triggered by teriflunomide, which may thus prove useful in the treatment of anemia in patients with malignancy [489]

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Myelination refers to the process in which nerves acquire a myelin sheath the insulating layer of tissue made up of lipids and proteins that surrounds nerve fibers