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Diabetes Care 2014, 37, S14S80

expanding understanding of its role in cell migration, wound healing, and angiogenesis [5,6]

3.3.3 Altered fatty acid metabolism affecting follicular growth HFD disrupts ovarian fatty acid metabolism by upregulating fatty acid uptake and trafficking (increased CD36, FABP expression), impairing -oxidation (reduced PPAR targets, CPT1, ACOX), and promoting lipid storage via PPAR-mediated FSP27/CIDE-C upregulation, leading to ectopic lipid accumulation, lipotoxicity, and oxidative stress compromising folliculogenesis at multiple stages (Di Berardino et al., 2022) (Yan et al., 2020

We administered 75 mg/kg caffeine and 100 mg/kg EGCG to observe the commonality and specificity of the two treatments in an HFHC-induced mouse model of NASH