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To induced the specifically knockout of Slc25a39 in neurons, Slc25a39 f/f : Map2-CreERT2 /+ mice were intraperitoneally injected with tamoxifen (75 mg each day, 5 consecutive days)

12.6 Pathways of biliverdin production from heme by chain-opening and bilirubin production by reduction of biliverdin (Reproduced with permission from Odell [15]) After its formation in reticuloendothelial cells, bilirubin is released into the bloodstream, where it is transported bound to albumin via one primary and two secondary binding sites

Cel Death Differ 23, 270278