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In addition, because BPC-157 is a gastric peptide, there have been some informal reports of digestive side effects like nausea, diarrhea, appetite changes, gas and bloating related to its administration

Inhibition of prostaglandin synthetase in brain explains the antipyretic activity of acetaminophen

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Absorption problems Even with adequate intake, absorption can be reduced by: Certain gastrointestinal conditions affecting the stomach or small intestine Some medications Age-related reduction in stomach acid (which can affect absorption) Autoimmune gastritis (often historically referred to as pernicious anaemia) This is a well-recognised cause of B12 deficiency and may require ongoing management