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The FDA first announced it would pursue regulatory changes to maximum nicotine levels in combustible smoking products in 2022 in an effort to reduce the public health effects related to addiction and minimize youth uptake

In a large study among 7130 participants of the Population Assessment of Tobacco and Health (PATH) Study, there was no difference in the biomarker concentration of inflammatory (high-sensitivity C-reactive protein, interleukin-6, fibrinogen, soluble intercellular adhesion molecule) and oxidative stress (urinary 8-isoprostane) between participants who used e-cigarettes and non-users 34

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