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Due to the large percentage of women utilizing nicotine products during pregnancy in the United States and globally, this review seeks to centralize pre-clinical and clinical studies focused on the neurobehavioral and neurodevelopmental complications associated with prenatal nicotine exposure (PNE) such as alterations to the hypothalamic-pituitary-adrenal (HPA) axis and brain regions such as the prefrontal cortex (PFC), ventral tegmental area (VTA), nucleus accumbens (NA), hippocampus, and caudate as well as changes to nAChR and cholinergic receptor signaling, long-term drug seeking behavior following PNE, and other related developmental disorders

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may impose, and the purchaser agrees to pay, $5 a day of any lot or item(s) not picked up by the purchaser or shipping arrangements complete with-in 14 days of the date of sale

10.1007/s00204-020-02766-7 46 ShiM.WesselingS.BouwmeesterH.RietjensI