Reagents The following antibodies and their corresponding Research Resource Identifiers (RRIDs) were used in this study: SLC25A39 (RRID: AB_2878095, AB_2605624), SLC25A40 (RRID: AB_1310678), AFG3L2 (RRID: AB_2637746, AB_1209606), HSP60 (RRID: AB_881444), -actin (RRID: AB_10950489), GAPDH (RRID: AB_307272), cleaved caspase-3 (RRID: AB_302962), cleaved caspase-9 (RRID: AB_2889070), cleaved PARP (RRID: AB_777102), HEY1 (RRID: AB_2576326), pro-caspase-3 (RRID: AB_2069711), pro-caspase-9 (RRID: AB_2809709), HES1 (RRID: AB_2546278), and NOTCH1 (RRID: AB_467579)
The emerging role of Nrf2 in mitochondrial function
It plays a key role in: A vitamin B12 deficiency can lead to symptoms such as fatigue, weakness, brain fog and tingling in the hands and feet
Researchers will need to do extensive clinical trials to be sure that a new drug really works and is safe to use