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At each visit, compliance with the study protocol was assessed by the investigator by asking open ended questions about taking the test supplement, the assigned diet, an exercise program, blood draws were conducted for assessment of IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3), fasting lipid panel (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides), fasting glucose, and HbA1c and participants completed the Revised Fibromyalgia Impact Questionnaire (FIQR) and Perceived Stress Scale (PSS)

Biochem Pharmacol 64, 10571064 (2002)

Synaptic and extrasynaptic NMDAR activation exert opposing neural protective and neurotoxic effects, respectively, and these processes involve a variety of corresponding neuroprotective and apoptotic pathways ( Metabotropic Glutamate Receptors Glutamate can also activate a type of G-protein-coupled receptors known as metabotropic glutamate receptors (mGluRs)