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The standard recommendation is one 500 mcg capsule twice daily on an empty stomach

However, theoretical concerns remain about long-term effects on glucose homeostasis with chronic use, particularly in individuals predisposed to diabetes

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(2009) demonstrated that retroviral overexpression of Olig2 in transplanted F3 human NPCs enhanced oligodendrocyte replacement accompanied by a significant increase in white matter sparing, decreased lesion size, increased myelin thickness and improved locomotor recovery compared to non-transduced F3 NPCs