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Cognitive decline and Alzheimer's disease A few observational studies have linked cognitive decline and Alzheimer's disease in older adults with inadequate status of folate, vitamin B 12 , and vitamin B 6 (60), although some meta-analyses have not found an association (61, 62)

Collectively, these limitations highlight that current PET MNPs research is constrained by detection limits, contamination risks, methodological bias, and insufficient standardisation

Since the production of melatonin with age is gradually decreasing, such an event may to some extent correlate with the development of many chronic diseases (Hardeland 2012)