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Microglia Microglia are tissue-resident macrophages ( Recognition of the NVU is of high importance to reach a better understanding of brain physiology and its behavior in different pathologies such as ischemic brain injury ( Transport Across the BloodBrain Barrier Despite this efficient barrier function for preventing the entrance of non-desirable compounds, the ECs of a healthy BBB also act as a filter, allowing a selective exchange of solutes and regulatory factors between the blood and the brain through a number of highly controlled routes (Figure 1)

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