The first experience available in the literature on an oral food supplement containing quercetin, and not contained within a plant ingredient of the compound, dates back to 2015, when Ariano conducted an open-label study with an oral supplement containing dry extract of Perilla frutescens 80 mg (containing several flavonoids), quercetin 150 mg, and vitamin D3 5 mcg (200 IU)
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study demonstrated that ipamorelin: Released GH in a dose-dependent manner Did not significantly elevate cortisol levels, even at high doses Did not significantly elevate prolactin levels Did not significantly affect ACTH, FSH, LH, or TSH (4) This selectivity gives ipamorelin a notably clean side-effect profile compared to other GH secretagogues
Its production decreases with age, hence the importance of supplementation