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It is widely acknowledged that gastrointestinal factors, such as glucagon like peptide (GLP)-1 and gastric inhibitory polypeptide (GIP), interact directly with -cells to induce proliferation, and enhance resistance to apoptosis, thereby increasing/maintaining -cell mass (136, 137)

Weight Management and Obesity Research: Cag has emerged as a significant compound in obesity research due to its ability to reduce food intake and support weight reduction through central appetite suppression

& Fishel, S

The minimization or even elimination of these kinds of variables can have a significant effect on the interpretation of metabolomic analyses