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Deletion of Nox1 resulted in a marked decrease of blood pressure in response to ATII treatment, 60 whereas its overexpression in vascular smooth muscle cells lead to a further blood pressure augmentation

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A phase of ionic edema is also sometimes referred to as an intermediate between cytotoxic and vasogenic edema, corresponding to the formation of extracellular edema with an undamaged BBB and impermeable BBB to larger molecules such as proteins (70, 71)