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It has been suggested that their use over many years could cause physical changes such as shrinkage of the cerebral cortex, as has been shown in chronic alcoholics, and that such changes may be only partially reversible after withdrawal

From the perspective of TCM, treatment must achieve treating both the symptoms and the root causes, correspondingly, we propose further exploration of potential interventions targeting pathogeneses involved in epileptogenesis from TCM, but not just focus on neural inhibitory mechanisms