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Frequency of administration In the case wherein the patient's condition does not improve, upon the doctor's discretion the administration of the compounds is administered chronically, that is, for an extended period of time, including throughout the duration of the patient's life in order to ameliorate or otherwise control or limit the symptoms of the patient's disease or condition

Eur Respir J 24 : 994999 Balzar S, Chu HW, Strand M, Wenzel S 2005 Relationship of small airway chymase-positive mast cells and lung function in severe asthma