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Overall, our data point to a mechanism involving MMP12 influence on pulmonary iron metabolism and asthmatic responses following iron-rich JUUL-menthol flavored ENDS aerosol exposures in an HDM-induced asthma model

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DISCUSSION In this sample of older US adults, childhood smoking was associated with poorer global physical and mental health in adulthood, extending previous studies that have found HRQOL associations with current smoking 3,6,7,21-28 , heaviness of current smoking 4 , pack-years of smoking 5 , secondhand smoke exposure 10,11 , and improvements with reducing 29 or quitting 9,28,30,31 smoking