It can lead to neuropathy, megaloblastic anemia, and pernicious anemia, [2] [13] causing symptoms including fatigue, paresthesia, depression, cognitive decline, ataxia, and even irreversible nerve damage
Bromfield EG, Walters JLH, Cafe SL, Bernstein IR, Stanger SJ, Anderson AL, et al
Neither form causes toxicity in routine doses
Current evidence suggests that cytosolic PGES (cPGES) and microsomal prostaglandin E synthase-2 (mPGES-2) are constitutively expressed in cells and are coupled with COX-1 and COX-1/-2, respectively (Murakami et al., 2 and, ideally, does not affect the formation of other housekeeping PGs (Koeberle et al., 2 in human epithelial cells, carcinoma cells (A549) and human whole blood treated with lip polysaccharides (LPS