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The same McCoy 2013 paper reported that Dihexa reversed scopolamine-induced deficits and improved learning in aged rats in the Morris water maze again, animal data, from a paper now carrying an Expression of Concern

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Age-Related Changes: Older adults often produce less stomach acid, which can hinder B12 absorption from food

Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex