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it appears to recapitulate the intracellular signals that exercise generates, including AMPK activation, mitochondrial biogenesis, and GLUT4 upregulation, in tissues that can no longer experience them through movement

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Arch Iran Med 21:289295 Georgescu D, Ancusa OE, Georgescu LA et al (2016) Nonmotor gastrointestinal disorders in older patients with Parkinsons disease: is there hope