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Cagrilintide vs semaglutide (Wegovy/Ozempic) Mechanism: Cagrilintide: Amylin receptor agonist Semaglutide: GLP-1 receptor agonist Different pathways Weight loss: Cagrilintide alone: 10-12% Semaglutide alone: 10-15% Similar efficacy monotherapy Gastric emptying: Cagrilintide: Very strong delay Semaglutide: Moderate delay Cagrilintide more powerful Side effects: Cagrilintide: More GI effects (stronger gastric slowing) Semaglutide: Moderate GI effects Cagrilintide harder to tolerate for some Availability: Cagrilintide: Investigational (not approved) Semaglutide: FDA approved, widely available Semaglutide easier to obtain currently Combination potential: Synergistic together (CagriSema) 15-25% weight loss combined Best of both mechanisms Verdict: Similar monotherapy efficacy, but combine for maximum results
Is it safe in animals
Hoshi E, Tremblay L, Fger J, Carras PL, Strick PL
Disclosure of interest: miriam caterino: nothing to disclose E-Posters - DIAGNOSIS / ETIOLOGY 04.00 - DIAGNOSIS / ETIOLOGY - 04.06 - CARDIOEMBOLISM & HEART-BRAIN INTERACTIONS P2453 - ESOC25-2484 DETERMINANTS OF HIGH-SENSITIVITY TROPONIN ELEVATION IN PATIENTS WITH ISCHEMIC STROKE AND TRANSIENT ISCHEMIC ATTACK Anna Komarova 1 , Andrey Shavarov 1 , Natalia Krivosheeva 1 , Kirill Eroshkin 1 , Vladimir Zhuravlev 1 , Eugenia Astapovich 1 , Regina Ostrikova 1 1 Botkin hospital, Moscow, Russian Federation Background and Aims: The availability of high-sensitivity (hs) diagnostic assays requires a precise understanding the full spectrum of cardiac and non-cardiac diseases to interpret elevated cardiac troponin (hs-cTn) levels
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