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Later, the same group confirmed HDAC inhibition by SFN in vivo , using the adenomatous polyposis coli multiple intestinal neoplasia mouse model that had ingested 443 mg SFN/kg (about 6 mol SFN/d) for 70 d, and observed the re-expression of p21 and bax genes that triggered cell-cycle arrest and apoptosis in transformed cells and microadenomas, thereby suppressing polyp formation compared with controls ( Reference Myzak, Dashwood and Orner 54 )

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[DOI] [PubMed] [Google Scholar] Miller LG