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[4] The folic acid injection products may contain aluminum which may reach toxic concentrations with prolonged administration in patients with renal failure, renal disease, renal impairment, or in premature neonates with immature kidneys

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The sperm mitochondria and lipid membrane are the two main regions where excessive ROS are produced [52]

This observation further strengthened the notion that additional binding free energy could be gained not only by forming meaningful interactions with the doorstop pocket but also by liberating the trapped waters