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Bei topischer Anwendung zeigen sich erste sichtbare Verbesserungen der Hautstruktur nach 46 Wochen , volle Effekte (Faltenreduktion, Elastizitt) nach 12 Wochen

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Short-term trials (412 weeks) report transient headaches in 1218% of participants and mild GI discomfort in 8%, with zero serious adverse events requiring discontinuation