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Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells

Nausea is the most frequently reported adverse effect, potentially affecting thirty to forty percent of patients at some point during treatment, though the intensity typically diminishes over time as tolerance develops

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