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The inverse relationship between coffee consumption and HCC is thought to be due to caffeine's alteration of liver signaling and inflammatory pathways, which lowers circulating levels of inflammatory biomarkers such as interferongamma (IFN), CX3CL1fractalkine, CCL4, FGF2, and sTNFRII (de Melo Pereira et al., 2020

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You live this crazy long life and you're in bed for the last 5 to 7 years of your life and you're hurting and you're like dealing with cancer or this, that, or just bam, hit by a shark