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Figure 1 T2DM is the most common type of diabetes mellitus, and it is widely recognised that insulin resistance (IR) plays a key role in the development of T2DM and its organ-related complications, but the pathogenesis of cognitive dysfunction in diabetes mellitus is not yet fully understood (5)

may help general brain health.(71) Taurine - amino acid that regulates cell to cell communication, often seen in energy drinks though the only evidence suggests nerve-calming effects.(72) Theobromine Caffeine-like compound sourced from cocoa believed to have stimulating properties with fewer side effects.(73) Turmeric - root herb supplies antioxidant complex linked to brain cell protection and long-range cognitive health.(74) Tyrosine precursor used to form brain chemicals tied to attention and focus

Thymosin Beta-4 Thymosin Beta-4 (T4) functions to reduce inflammation and promote tissue regeneration through actin sequestering and cell migration support, enabling repair of ovarian or testicular tissue following insult

BA physiology is diversely altered in Insr P1195L/ + /HFD mice P1195L/ + As fat-specific insulin receptor deficient mice (FIRKO mice) failed to exhibit glucose intolerance, we examined the contribution of insulin resistance in liver