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This includes upregulation of antioxidant enzymes (superoxide dismutase, catalase) that protect against oxidative damage, enhancement of growth factor expression (TGF-, VEGF, PDGF) that supports tissue repair, and suppression of inflammatory gene expression that contributes to chronic skin degradation

[2] However, unexplained elevation warrants investigation for underlying pathology, particularly hepatic or haematological disease

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34 The HLA-B*1502 allele is almost exclusively seen in patients with Asian ancestry, and these patients have a higher risk of SJS and DRESS with antiepileptic agents