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Plasma concentrations decline significantly with age from ~200 ng/mL at age 20 to ~80 ng/mL by age 60 making it a compelling target for age-related tissue maintenance and periodontal health

*Correspondence: Antonio Di Sabatino, [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers