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It has been shown that neutrophils release elastase and PR3 together with aggNETs, which can then engulf and degrade MSU crystals, thus preventing further activation of the NLRP3 inflammasome and subsequent release of pro-inflammatory cytokines like IL-1 and IL-18 (Figure 3)

NSAID toxicity Gastrointestinal NSAID toxicity is managed by minimizing NSAID exposure, or pairing the NSAIDs with drugs that protect the integrity of the GI tract

Legionella pneumophila , the causative agent of Legionnaires disease, deploys a Type IV secretion system (T4SS) to translocate over 300 effectors into host cells