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Activation of the cAMP/PKA pathway induces loss of stress fibers (112), activation of regular arrangement of collecting venules (Rac) and Cell Division Cycle 42 (Cdc42) (113, 114), formation of filamentous pseudopods and lamellar pseudopods (114, 115) microfilament assembly (116), and inhibition of the Rho family of GTPases activity (117, 118), events which happen at the tip of migrating cells

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Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes