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Did you know that, while histamine plays a vital role in the body as part of our immune, digestive and nervous systems, problems arise when there is either too much histamine in circulation or a reduced ability to break it down

Other signs and symptoms of ALS include: Tripping and falling Difficulty walking Difficulty with normal daily activities Hand weakness or clumsiness (dropping things) Weakness in the legs, feet, or ankles Abnormal fatigue of the arms and/or legs Slurred speech Trouble swallowing Muscle cramps and twitches Uncontrollable periods of laughing, crying or yawning Cognitive and behavioral changes Shortness of breath is a common symptom of ALS due to the effect on the breathing muscles

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This finding indicates that epigenetic variation, which may well be susceptible to contextual and other environmental influences, has a greater effect on serum UA than the identified genetic factors and certainly deserves further investigation in PD