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BPC-157 (Body Protection Compound-157), a synthetic gastric peptide analogue, and Thymosin Beta-4, an actin-sequestering protein fragment, demonstrate mechanisms of action directly relevant to the vascular and connective tissue dysfunction underlying chronic hemorrhoids

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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation