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These Cu I binding properties are potentially consistent with a role in Cu storage under Cu-replete or Cu-toxic conditions, 898 or as part of an anticipatory Cu-toxicity response, when cells are chronically metal-starved, and thus particularly vulnerable to mismetalation mediated by even modest Cu toxicity (see Section 5.3.2)

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Ghezzo A, Visconti P, Abruzzo PM, Bolotta A, Ferreri C, Gobbi G, Malisardi G, Manfredini S et al (2013) Oxidative stress and erythrocyte membrane alterations in children with autism: correlation with clinical features