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In a murine intratracheal inoculation model, TMV was detected within lung tissue and localized in the cytoplasm of alveolar macrophages, persisting for up to 14 days despite the absence of productive replication ( These findings indicate that TMV is not merely an environmental contaminant but can access the respiratory microenvironment in vertebrate hosts

The same pattern held up in smokers. DNA damage to oral epithelial cells, which line the mouth, is an early change that is associated with an increased risk for many types of chronic disease, including cancer and inflammatory diseases