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Current clinical or preclinical data suggest that long-acting amylin analogues have the potential to achieve weight loss equivalent to that of GLP-1 receptor agonists but with better tolerability, providing a better experience for patients and achieving high-quality weight loss by preserving lean muscle mass

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It was previously approved by the FDA for diagnostic evaluation and treatment of pediatric GH deficiency and is now widely used off-label in research and clinical settings to address adult-onset GH insufficiency and age-related hormonal decline.