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Retatrutide is a more recently developed investigational compound a triple agonist targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously

Preclinical safety at tested doses has been reasonable, but human long-term safety data are not established

Oral and sublingual B12 supplements are readily available, but the general consensus is that intramuscular injections of B12 are the most effective and efficient means of delivery