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The protocol from Celsis for assessing microsomal-dependent drug metabolism was followed with minor adaptations

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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

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Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis

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